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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Cancer J. 2014 Jul-Aug;20(4):256–261. doi: 10.1097/PPO.0000000000000061

Figure 3.

Figure 3

B7-H1 expression and TILs. Four different melanoma groups with potential implication for mechanism and therapy have been identified according to B7-H1 expression and the presence of TILs inmelanoma biopsies: I, B7-H1–negative tumors without TILs, considered as a immunological ignorance because immune cells do not go to the tumor site; II, B7-H1–positive tumors with TILs, considered as a paradigm of adaptive resistance of tumor mediated by B7-H1/PD-1 pathway; III, B7-H1–negative tumors with TILs, considered as a situation of tolerance because TILs are present, but they are not inducing B7-H1 expression in tumor microenvironment through IFN-γ production; and IV, B7-H1–positive tumors without TILs, considered as a scenario of intrinsic induction of B7-H1 expression in tumor cells. TILs, tumor infiltrating lymphocytes. Adapted from Szol and Chen,25 Copyright ©2013, with permission from the American Association for Cancer Research.