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. 2015 Jun 4;13:38. doi: 10.1186/s12951-015-0097-1

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© Feugang et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fluorescence imaging of follicular micro-sections following QD-BRET (QD) labeling. The upper panel shows the intracellular progression of the fluorescence signals of QD1− nanoparticles during culture (Day 1, 2, and 4). Fluorescence signals were mainly detected in the mural granulosa cells, surrounding the follicular cavity, on Day 1 post microinjection. The fluorescence signal progressed into the mid-section of the follicle wall (theca internal cells) on Day 2, and then the entire follicle wall, including the theca external cells on Day 4. The bottom panel represents the corresponding overlays fluorescence and visible lights. The intra-follicular COCs also incorporated the QD1− (200×). Arrows indicate the extent of tissue layers (GC granulosa cells, TI theca internal, TE theca external). The white arrows show detached and stained granulosa cells within the follicular antrum (FA).