Table 1.
Sample information and analyses results for amoxicillin
| Drug (total no of samples) | Brand; manufacturer; country of manufacture | Country of purchase | Expiry date (month-year) | Strength (mg) | MiniLab® CT | MiniLab® TLC test | HPLC content analysis adherence | Dissolution test compliance |
|---|---|---|---|---|---|---|---|---|
| Co-Trimoxazol; Letap Pharmaceuticals Ltd; Ghana | Ghana | Apr-12 | 250 | Pass | Pass | Yes | Yes | |
| Amoxicillin; Ayrton Drug Mfg; Ghana | Ghana | Oct-13 | 250 | Pass | Pass | Yes | Yes | |
| Amoxicillin 250 mg; GR Industries Ltd; Ghana | Ghana | Jan-14 | 250 | Pass | Pass | Yes | Yes | |
| Amoxylex; Luex Healthcare; United Kingdom | Ghana | Jun-12 | 250 | Pass | Pass | Yes | Yes | |
| Permoxyl 500; Ernest Chemicals; Ghana | Ghana | Jan-14 | 500 | Pass | Fail | Yes | Yes | |
| Promox capsules 500 mg; Medreich PLC; United Kingdom | Ghana | Jan-13 | 500 | Pass | Fail | Yes | Yes | |
| Amoram 500 mg capsules; LPC Medical (UK) Ltd; United Kingdom | Ghana | Oct-12 | 500 | Pass | Pass | Yes | Yes | |
| Amoxicillin 500 mg; GR Industries; Ghana | Ghana | Apr-12 | 500 | Pass | Pass | Yes | Yes | |
| Floximox; Evans Medical; Nigeria | Nigeria | Not stated | 250 | Pass | Pass | No | Yes | |
| Amoxicillin capsules (N = 20) | Amoxil; Beecham/Medreich; India | Nigeria | Apr-13 | 250 | Pass | Pass | Yes | Yes |
| Reichamox®; Medreich; India | Nigeria | Sep-11 | 250 | Pass | Pass | Yes | Yes | |
| Moxitin-500 Amoxicillin capsules B.P.; Clarion Medical; China | Nigeria | Oct-13 | 500 | Pass | Pass | Yes | Yes | |
| Amoxicillin 250 mg capsules BP; Milpharm Ltd; United Kingdom | United Kingdom | Aug-12 | 250 | Pass | Pass | Yes | Yes | |
| Amoxicillin capsules BP; Actavis; United Kingdom | United Kingdom | Nov-11 | 250 | Pass | Pass | yes | Yes | |
| Amoxil® capsules 250 mg; GSK; United Kingdom | United Kingdom | Jan-14 | 250 | Pass | Pass | Yes | Yes | |
| Amoxicillin 250 mg capsules; Medreich PLC; England | United Kingdom | Nov-12 | 250 | Pass | Pass | Yes | Yes | |
| Ranbaxy Amoxicillin; Ranbaxy; Ireland | United Kingdom | Jan-12 | 250 | Pass | Pass | Yes | Yes | |
| Amoxicillin 500 mg capsules; Athlone Laboratories; Ireland | United Kingdom | Feb-15 | 500 | Pass | Pass | Yes | Yes | |
| Amoxicillin 500 mg capsules; Accord Healthcare Limited; United Kingdom | United Kingdom | Nov-13 | 500 | Pass | Pass | Yes | Yes | |
| Amoxicillin capsules; Amoxicillin Trihydrate; Morningside Pharmaceuticals; United Kingdom | United Kingdom | Jul-11 | 500 | Pass | Pass | Yes | Yes | |
| Total passed (%) | 20/20 (100.0) | 18/20 (90.0) | ||||||
| Total failed (%) | 2/20 (10.0) | |||||||
| Total compliant with USP tolerance limits (%) | 19/20 (95.0) | 20/20 (100.0) | ||||||
| Total noncompliant with USP tolerance limits (%) | 1/20 (5.0) | |||||||
CT = colorimetric test; GSK = GlaxoSmithKline group of companies; HPLC = high-performance liquid chromatography; TLC = thin-layer chromatography; USP = U.S. Pharmacopeia.
The USP content limits state that 90–120% of the stated dose of amoxicillin must be measured for the tablets to be classified as compliant.