Table 6.
(a) All ACTs analyzed (N = 1,281) | ||||||||
---|---|---|---|---|---|---|---|---|
Partner drug | ||||||||
Artemisinin component | %API | 55–65 | 65–75 | 75–85 | 85–115 | 115–125 | > 125 | Total |
55–65 | < 0.1 | 0 | 0.1 | < 0.1 | < 0.1 | 0 | 0.2 | |
65–75 | 0 | 0.1 | 0 | < 0.1 | 0 | 0 | 0.2 | |
75–85 | 0 | 0 | < 0.1 | 1.7 | 0.1 | 0 | 1.9 | |
85–115 | 0 | 0 | 3.3 | 87.9 | 2.7 | 0.6 | 94.4 | |
115–125 | 0 | < 0.1 | 0 | 1.4 | 1.5 | 0 | 2.9 | |
> 125 | 0 | 0 | 0 | 0.2 | 0.1 | 0 | 0.3 | |
Total | < 0.1 | 0.2 | 3.4 | 91.3 | 4.5 | 0.6 | 100 | |
(b) Alu (N = 504) | ||||||||
Lumefantrine | ||||||||
Artemether drugs | %API | 55–65 | 65–75 | 75–85 | 85–115 | 115–125 | > 125 | Total |
55–65 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | |
65–75 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | |
75–85 | 0 | 0 | 0 | < 0.1 | 0 | 0 | < 0.1 | |
85–115 | 0 | 0 | 0.2 | 96.9 | 1.0 | 0 | 98.0 | |
115–125 | 0 | 0 | 0 | 1.4 | 0 | 0 | 1.4 | |
> 125 | 0 | 0 | 0 | 0.6 | 0 | 0 | 0.6 | |
Total | 0.0 | 0.0 | 0.2 | 98.9 | 1.0 | 0.0 | 100 | |
(c) Artemisinin–piperaquine (N = 173) | ||||||||
Piperaquine | ||||||||
Artemisinin | %API | 55–65 | 65–75 | 75–85 | 85–115 | 115–125 | > 125 | Total |
55–65 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | |
65–75 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | |
75–85 | 0 | 0 | 0 | 3.6 | 0 | 0 | 3.6 | |
85–115 | 0 | 0 | 0.9 | 88.5 | 2.7 | 4.3 | 96.4 | |
115–125 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | |
> 125 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | |
Total | 0.0 | 0.0 | 0.9 | 92.1 | 2.7 | 4.3 | 100 | |
(d) Artesunate–mefloquine (N = 310) | ||||||||
Mefloquine | ||||||||
Artesunate | %API | 55–65 | 65–75 | 75–85 | 85–115 | 115–125 | > 125 | Total |
55–65 | <0.1 | 0 | 0.6 | <0.1 | 0.2 | 0 | 1.0 | |
65–75 | 0 | 0.6 | 0 | 0.4 | 0 | 0 | 1.0 | |
75–85 | 0 | 0 | 0 | 0.9 | 0.6 | 0 | 1.5 | |
85–115 | 0 | 0 | 0.3 | 80.8 | 3.7 | < 0.1 | 84.9 | |
115–125 | 0 | 0.2 | 0 | 3.4 | 7.5 | 0 | 11.2 | |
> 125 | 0 | 0 | 0 | 0 | 0.6 | 0 | 0.6 | |
Total | < 0.1 | 0.8 | 0.9 | 85.5 | 12.6 | < 0.1 | 100 | |
(e) Dihydroartemisinin–piperaquine (N = 294) | ||||||||
Piperaquine | ||||||||
Dihydroartemisinin | %API | 55–65 | 65–75 | 75–85 | 85–115 | 115–125 | > 125 | Total |
55–65 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | |
65–75 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | |
75–85 | 0 | 0 | 0.2 | 4.1 | 0 | 0 | 4.2 | |
85–115 | 0 | 0 | 11.6 | 78.9 | 4.7 | 0.1 | 95.3 | |
115–125 | 0 | 0 | 0 | 0.4 | 0 | 0 | 0.4 | |
> 125 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | |
Total | 0.0 | 0.0 | 11.8 | 83.4 | 4.7 | 0.1 | 100 |
ACT = artemisinin-based combination therapy; Alu = artemether–lumefantrine; API = active pharmaceutical ingredient.
The percentage of samples containing acceptable quantities of API for both the artemisinin component and partner drug is shown in bold.