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. 2015 May 26;6:7219. doi: 10.1038/ncomms8219

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(a) Polymerization free energy (F_p) as a function of end-to-end distance (d) between the incoming N-BAR molecule and a linear chain with: 3 N-BARs, 1 N-BAR or 5 N-BARs, as depicted at the bottom of each plot. For all plots, measurement done from two independent umbrella-sampling calculations, each using 34 different sampling windows (except at zero tension, where 46 windows were used), each window run for 100,000 time steps. (b) Magnitude of F_p and the interaction length scale (λ) as a function of membrane tension (σ) for the three chain lengths, where N is the total number of proteins in the chain. Dots represent free-energy minima taken from measurements in a. Cross marks denote values obtained using , where κ=15 k_BT.

Inline graphic — (a) Polymerization free energy (F_p) as a function of end-to-end distance (d) between the incoming N-BAR molecule and a linear chain with: 3 N-BARs, 1 N-BAR or 5 N-BARs, as depicted at the bottom of each plot. For all plots, measurement done from two independent umbrella-sampling calculations, each using 34 different sampling windows (except at zero tension, where 46 windows were used), each window run for 100,000 time steps. (b) Magnitude of F_p and the interaction length scale (λ) as a function of membrane tension (σ) for the three chain lengths, where N is the total number of proteins in the chain. Dots represent free-energy minima taken from measurements in a. Cross marks denote values obtained using , where κ=15 k_BT.