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. 2015 Jun 4;5:10893. doi: 10.1038/srep10893

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Copyright © 2015, Macmillan Publishers Limited

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(A, B) Computational modelling of HDAB binding to PARP-1 and PARP-2. (C) The inhibitory effect of HDAB on PARP-1 activity was measured using a PARP Assay Kit. The data from three independent experiments are expressed as relative inhibition rates; the inhibition rate in the control was set to 0. (D) Clonogenic survival assays of HDAB for MCF-7 and MDA-MB-436 human breast cancer cells. (E) Clonogenic survival assays of 3-AB for MCF-7 and MDA-MB-436 human breast cancer cells. Three independent experiments were performed and the data are presented as the mean ±SD. The colony formation of non-treated cells was set to 100.