Table 4.
Summary of treatment difference in change between baseline and week 52 for laboratory parameters
| Parameter | Vitamin D Analog Change Mean (SEM) | Cinacalcet Change Mean (SEM) | Difference (Cinacalcet − Vitamin D Analogs) Mean (SEM) | 95% CI for Mean Difference | P Value |
|---|---|---|---|---|---|
| FGF-23 (ng/L) | 138.9 (27.8) | −107.5 (26.8) | −246.3 (38.7) | −322.6 to −170.0 | <0.001a |
| PTH (pg/ml) | −78.9 (42.6) | −147.3 (47.2) | −68.4 (63.6) | −193.6 to 56.90 | 0.28 |
| Calcium (mg/dl) | 0.20 (0.06) | −0.86 (0.08) | −1.06 (0.10) | −1.26 to −0.87 | <0.001 |
| Phosphorus (mg/dl) | 0.005 (0.160) | −0.617 (0.170) | −0.622 (0.234) | −1.08 to −0.16 | <0.001 |
| Ca×P (mg2/dl2) | 1.26 (1.51) | −10.26 (1.55) | −11.52 (2.16) | −15.78 to −7.27 | <0.001 |
Median, quartile 1, quartile 3, and interquartile range for change from baseline: cinacalcet: −49.5, −183.8, 17.3, and 201.1; vitamin D analogs: 70.3, 0, 307.8, and 307.8.
a
Wilcoxon rank sum test (nonparametric): P value <0.001.