Table 2.
Crude and adjusted hazard ratios (95% confidence intervals) for mortality (overall and pre-ESRD mortality) according to glycated hemoglobin values
| Overall Mortality | ||||
|---|---|---|---|---|
| HbA1c (%) | No. of Events/n | Crude HR | mGFR-Adjusted HR | Fully Adjusted HRa |
| Tertiles | ||||
| 1 (<5.3) | 27/335 | 1 (ref) | 1 (ref) | 1 (ref) |
| 2 (5.3–5.7) | 30/390 | 1.13 (0.67 to 1.91) | 1.20 (0.71 to 2.03) | 1.07 (0.60 to 1.88) |
| 3 (5.7–6.5) | 52/440 | 2.05 (1.28 to 3.29) | 2.18 (1.36 to 3.51) | 1.79 (1.06 to 3.00) |
| P value for trend | 0.002 | <0.001 | 0.02 | |
| Continuous | 109/1165 | 1.88 (1.24 to 2.86) | 1.98 (1.31 to 2.98) | 1.66 to (1.07 to 2.58) |
| P value | 0.003 | 0.001 | 0.02 | |
| Pre-ESRD Mortality | ||||
| HbA1c (%) | No. of Events/n | Crude HR | mGFR-Adjusted HR | Fully Adjusted HRa |
| Tertiles | ||||
| 1 (<5.3) | 14/335 | 1 (ref) | 1 (ref) | 1 (ref) |
| 2 (5.3–5.7) | 22/390 | 1.39 (0.71 to 2.72) | 1.36 (0.69 to 2.65) | 1.23 (0.60 to 2.54) |
| 3 (5.7–6.5) | 36/440 | 2.38 (1.28 to 4.42) | 2.28 (1.23 to 4.22) | 2.00 (1.02 to 3.92) |
| P value for trend | 0.004 | 0.01 | 0.03 | |
| Continuous | 72/1165 | 2.16 (1.27 to 3.68) | 2.07 (1.22 to 3.51) | 1.85 (1.05 to 3.24) |
| P value | 0.01 | 0.01 | 0.03 | |
HbA1c, glycated hemoglobin; ref, reference; HR, hazard ratio; mGFR, measured GFR.
a
Adjusted for measured GFR, age, sex, body mass index (<19, 20–24, 25–29, ≥30), race (black/other), urinary protein/creatinine ratio (log), elevated BP (>140/90 mmHg), history of cardiovascular disease (yes or no), smoking status (current smoker, former smoker, or never smoker), angiotensin-converting enzyme inhibitor or antireceptor blocker treatment, and serum albumin (>3.5 g/dl or <3.5 g/dl).