Table 3.
Comparison of the estimated association of induction treatments on acute rejection at 1 year using multivariable logistic regression models
| Multivariable Model | Induction Type | OR (95% CI) | P Value |
|---|---|---|---|
| Steroid | |||
| Logistic regression | |||
| IL-2 RA | 1 | ||
| r-ATG | 0.80 (0.71 to 0.89) | <0.001 | |
| No induction | 1.04 (0.92 to 1.16) | 0.55 | |
| PS-weighted logistic regression | |||
| IL-2 RA | 1 | ||
| r-ATG | 0.78 (0.70 to 0.88) | <0.001 | |
| No induction | 0.96 (0.86 to 1.08) | 0.48 | |
| No Steroid | |||
| Logistic regression | |||
| IL-2 RA | 1 | ||
| r-ATG | 0.72 (0.58 to 0.90) | 0.004 | |
| Alemtuzumab | 0.52 (0.40 to 0.66) | <0.001 | |
| PS-weighted logistic regression | |||
| IL-2 RA | 1 | ||
| r-ATG | 0.73 (0.59 to 0.90) | 0.004 | |
| Alemtuzumab | 0.53 (0.42 to 0.67) | <0.001 |
Adjusted for donor factors (age, sex, and race), recipient factors (age, sex, race, cardiovascular morbidity, panel reactive antibody, retransplant status, and dialysis status) and transplant factors (donor/recipient weight ratio, HLA mismatch, and transplant year). PS, propensity score; IL2-RA, IL-2 receptor antagonist; r-ATG, rabbit anti-thymocyte globulin; OR, odds ratio; 95% CI, 95% confidence interval.