Gogtay 2004

Methods	Allocated by "simple, computer-generated randomization code"
Participants	Twenty-two patients in Mumbai, India Inclusion criteria: 1. = 18 years 2. Normal G6PD 3. = 55 P. falciparum gametocytes/μL on admission
	Exclusion criteria: 1. Complicated malaria
Interventions	1. Quinine days 1 to 7: 30 mg/kg/day + PQ (45 mg) 2. Quinine days 1 to 7: 30 mg/kg/day + bulaquine (approximately 75 mg base)
Outcomes	Asexual and gametocyte counts on days 1, 4, 8, 15, 22 and 29 Adverse events
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer-generated randomization.
Allocation concealment (selection bias)	Unclear risk	Not reported.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No evidence of incomplete data.
Selective reporting (reporting bias)	Low risk	No evidence of selective reporting.
Other bias	High risk	Unbalanced allocation (9 versus 13) and small number of participants.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not reported.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Laboratory technician reading blood smears was blinded.