Singhasivanon 1994

Methods	Individually RCT Dates of trial: not stated.
Participants	23 people with uncomplicated P. falciparum malaria, parasitaemia between 1 to 5 per 1000 rbc. Age 5 to 12 years, sex not stated. Exclusion criteria: Antimalarial drugs, urine with quinoline and sulfonamide drugs, other diseases, hematocrit ≤ 20%, inability to take oral medication.
Interventions	1. MSP: MQ 20 mg/kg; S 40 mg base/kg; P 2 mg/kg; single dose 2. MSP + PQ: As above plus PQ 0.75 mg/kg single dose. MSP+PQ crushed and mixed with 30 mL syrup (83% dextrose)
Outcomes	1. Gametocyte clearance time (days) (assessed twice daily until negative, then once daily, by blood slide) 2. Adverse drug reactions, assessed once daily in first week then once a week 3. Parasite clearance time (hrs) 4. Fever clearance time (hrs) 5. Cure rate
Notes	Those who vomited within three hours of Rx were excluded - this is a post randomization exclusion.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information given.
Allocation concealment (selection bias)	Unclear risk	No information given.
Incomplete outcome data (attrition bias) All outcomes	High risk	Outcomes only reported for 18 of the 23 participants.
Selective reporting (reporting bias)	Unclear risk	No information given.
Other bias	High risk	Those who vomited within three hours of Rx were excluded- this is a post randomization exclusion.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not stated.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not stated.