Study	Reason for exclusion
Baird 2002	Outcome is cure of asexual infection. No gametocyte outcomes.
Barber 1929	Not a RCT or quasi-RCT. No controls.
Barber 1932	MDA with PQ; no other drug.
Brueckner 1998	Participants were not infected. Safety only trial.
Bunnag 1980	Comparison of SP plus either five day PQ 15 mg, single dose PQ 30 mg or single dose PQ 45 mg in patients with and without gametocytes at presentation. No regimen without PQ. Not a RCT or quasi-RCT. Authors state they will do further studies, including transmission. No difference in gametocyte outcomes between regimens, and gametocytes persisted for up to 21 days.
Burgess 1961	Comparison of 15 mg, 30 mg and 45 mg dose of PQ. Outcomes were gametocyte prevalence, density, percent of mosquitoes infected and mean oocysts per mosquito up to eight days. Not a RCT or quasi-RCT. No other drug. Although this trial used different doses by group (12 participants total), they were assigned to participants based on age or body size, and therefore it was not a valid comparison of different doses.
Cai 1985	Not a RCT.
Carter 2011	No 8AQ in trial.
Che 1987	No mention of randomization. No valid comparison group (pyronaridine phosphate plus sulfadoxine plus PQ versus pyronaridine phosphate only).
Che 1990	No appropriate control group.
Chevalley 2010	In vitro studies only. Not a RCT.
Clyde 1962	All patients got PQ.
Clyde 1970	Individual before-and-after study, but small number of patients and not controlled.
Clyde 1971	Individual before-and-after study, but small number of patients and not controlled.
da Silva 1984	Trial of treatment regimens, some including PQ, for P. vivax and P. falciparum.
Degowin 1966	No 8AQ in trial.
Doi 1989	Community observational study. Except for a small pilot study, everyone in the intervention villages got PQ. There no 'before' data from these villages. In the control site, some children received treatment.
Giao 2004	No appropriate control group (trial of CV8 (contains PQ) versus atovaquone-proguanil).
Gogtay 1999	Compares QN+PQ against QN+bulaquine. Not a relevant comparison.
Gunders 1961	Before-and-after studies of gametocytes and mosquito feeds on people with gametocytes given pyrimethamine and PQ in doses ranging from 10 mg to 40 mg base. No group without other drug.
Hii 1987	Controlled before-and-after study comparing SP+PQ+ITN versus SP+PQ only. Only one cluster per arm and no group without PQ.
Huang 1993	Not a RCT. Unbalanced groups.
Huang 1996	PQ given to both intervention groups in same regimen. Malaria treatment regimen was varied (low and higher dose pyronardine/SP).
Huang 2001	No gametocyte outcomes.
Jeffery 1956	Non-randomized comparison of gametocytes and infectivity of artificially infected patients treated with CQ or CQ+PQ.
Jeffery 1963	Observational study of gametocytes and infectivity of two patients given PQ.
Jerace 1933	Case series studying gametocytes and infectivity of patients given PQ.
Kaneko 1989	Non-randomized community trial comparing SP+PQ in one village with SP only in another. Only one cluster per arm. The trial was predominantly mass fever test and treat but 75% of people in the intervention village were treated versus 18% in the control village.
Karbwang 1991	Not randomized, no gametocyte outcomes.
Karbwang 1992	Pharmacokinetic study; no gametocyte outcomes or control group.
Kyaw 1994	No control group. All patients got PQ.
Li 2007	No gametocyte outcomes.
Li 2010	No gametocyte outcomes.
Lin 2004	All patients got PQ.
Mackerras 1949	No other malaria treatment; one patient fed on before and after PQ.
Rieckmann 1968	Two patients given 45 mg PQ only and fed on by mosquitoes before and after. No other malaria treatment or control group.
Rieckmann 1969	18 patients given CQ alone (N = 2), CQ plus 45 mg PQ (N = 3), or PQ alone in doses ranging from 15 to 45 mg, at either single dose or at one to two week intervals, and fed on before and after one of the doses of PQ. Non-randomized or quasi-randomized.
Santana 2007	Study of 14 day regimen of 15 mg PQ. Some P. falciparum cases were included but study did not distinguish between the patients with P. falciparum and P. vivax. Study was a comparison of association between methaemoglobinaemia after 14 day PQ in people with and without G6PD deficiency.
Shah 2013	Review of 21 trials from national drug resistance monitoring system of India. Compares 9 sites where AS+SP+PQ was used with 12 sites where it was not.
Shekalaghe 2010	Randomized comparison of anaemia after SP+AS+PQ versus placebo. Children with haemoglobin < 8 g were excluded from receiving PQ.
Shekalaghe 2011	Trial was a comparison of SP+AS+PQ versus placebo. No comparison of groups with and without PQ.
Sun 2011	Artesunate + PQ versus Quinimax only. No appropriate control group.
Suputtamongkol 2003	Comparison of MQ+AS versus MQ + PQ. No appropriate control group.
Tangpukdee 2008	Comparison of Artequick (contains PQ) with MQ+AS. No appropriate control group and no gametocyte outcomes.
Yang 1989	All patients got PQ, though different doses of PQ and other malaria treatments.
Yeramian 2005	PQ given only to P. vivax patients for 14 days.
Young 1959	No other malaria treatment; case series of PQ given either daily, twice a week or weekly to Pf patients.