Arango 2012

Methods	Quasi-RCT: alternate allocation to AQ+SP and AQ+SP+PQ, then MQ+AS and MQ+AS+PQ
Participants	Inclusion criteria: 1. Uncomplicated malaria 2. Pf only 3. Not pregnant 4. Voluntary consent Colombia 82 patients, aged one to 75 years (mean age ranged from 24 to 35 years in four groups) Gametocytes in 23/82 (28%)
Interventions	All loose combinations: 1. AQ+SP 2. AQ+SP+PQ 3. MQ+AS 4. MQ+AS+PQ AQ: 25 mg/kg total dose divided into 10 mg/kg on day 1 and 7.5 mg/kg on days 2 and 3 SP: 25 mg/kg/1.25 mg/kg single dose on day 1 MQ: 25 mg/kg total dose, divided into 8.3 mg/kg per day for 3 days AS: 4 mg/kg per day for 3 days PQ: 0.75 mg/kg, total single dose on day 2
Outcomes	Day 1 (pretreatment with schizonticide), 4 and 8 Asexual and gametocyte counts in thick smears Gametocyte prevalence Gametocyte density
Notes	No mention of G6PD status
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Alternate allocation.
Allocation concealment (selection bias)	Unclear risk	Not discussed.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No evidence of incomplete data.
Selective reporting (reporting bias)	Low risk	No evidence of selective reporting.
Other bias	Unclear risk	Nothing obvious.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not discussed.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not discussed.