Chen 1994
| Methods | Possibly individually RCT (stated to be randomized but no information given). Dates of trial not reported. | |
| Participants | 27 patients with slide positive P. falciparum including both asexual stages and gametocytes. No information given on age or sex. All dosages appear to be adult dosages. Site: malaria-endemic Hainan Island, China. Exclusion criteria: history of antimalarial treatment for present attack. | |
| Interventions | 1. Artemisinin: 1200 mg per day for 5 days (not included in review) 2. MQ 750 mg single dose day 1 (reported as day 0) 3. MQ 750 mg single dose + PQ 45 mg single dose day 1 (reported as day 0) | |
| Outcomes | 1. Gametocyte density: days 5, 8, 15, 22 and 29 (reported in paper as days 4, 7, 14, 21 and 28 since first day was day 0). Given as % of initial density on chart only 2. Percentage of participants infectious to An. dirus: days 5, 8, 15 and 22 (reported as days 4, 7, 14 and 21) 3. Percentage of mosquitoes infected: days 5, 8, 15 and 22 (reported as days 4, 7, 14 and 21) | |
| Notes | For gametocyte density, graph only of percentages; no raw numbers given except range of asexuals and gametocyte numbers reported for each group on day 1 (reported as day 0). | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | No information on sequence generation. Trial authors described process as participants "divided into groups A, B, and C". Equal number in each group and lack of detail suggests randomization not done adequately. |
| Allocation concealment (selection bias) | High risk | No data to suggest any measures to conceal allocation. |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | No missing participants in intervention groups 2 and 3. |
| Selective reporting (reporting bias) | Low risk | No obvious selective reporting. |
| Other bias | Low risk | No indication of other bias. |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported. |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not reported. |