Table 4.
AUC of gametocyte density over time, days 1 to 43 after treatment
| Other malaria treatment type | Trial | Malaria treatment | Dose PQ | AUC with PQ days 1 to 43 | AUC without PQ days 1 to 43 | % reduction AUC days 1 to 43 | log(10)AUC with PQ days 1 to 43 | log(10)AUC without PQ days 1 to 43 | % reduction log(10)AUC days 1 to 43 |
|---|---|---|---|---|---|---|---|---|---|
| Non-artemisinin- based | Kolaczinski 2012 | CQ | 0.5 | 71.02 | 279.13 | 74.6 | 1.85 | 2.45 | 24.3 |
| SP | 0.5 | 85.47 | 445.65 | 80.8 | 1.93 | 2.65 | 27.1 | ||
| Artemisinin- based | Shekalaghe 2007 | AS+SP | 0.75 | 1.16 | 3.22 | 64.1 | 0.06 | 0.51 | 87.5 |
| Smithuis 2010 | AS+AQ | 0.75 | 3.36 | 19.29 | 82.6 | 0.53 | 1.29 | 59.1 | |
| AL | 0.75 | 4.70 | 8.12 | 42.1 | 0.67 | 0.91 | 26.1 | ||
| AS+MQ fixed | 0.75 | 5.73 | 12.75 | 55.0 | 0.76 | 1.11 | 31.4 | ||
| AS+MQ loose | 0.75 | 4.37 | 7.74 | 43.5 | 0.64 | 0.89 | 27.9 | ||
| DHAP | 0.75 | 7.38 | 25.49 | 71.1 | 0.87 | 1.41 | 38.3 | ||
| Sutanto 2013 | DHAP | 0.75 | 32.73 | 83.15 | 60.6 | 1.51 | 1.92 | 21.1 | |
| Vasquez 2009 | AS+MQ | 0.75 | 12.53 | 8.87 | -41.3 | 1.10 | 0.95 | -15.8 | |
Abbreviations: AUC = area under curve; PQ = primaquine; CQ = chloroquine; SP = sulfadoxine-pyrimethamine; AS = artesunate; AQ = amodiaquine; AL = artemether-lumefantrine; MQ = mefloquine; DHAP = dihydroxyartemisinin-piperaquine.