Table 3.
Trial ID | Year of study | Age limits | Quinine dosing schedule | Artemether dosing schedule | ||||
Loading dose | Maintainance | Follow‐on therapy | Loading dose | Maintainance | Follow‐on therapy | |||
Hien 1996 VNM | 1996 | 15 to 79 yrs | 20 mg/kg IM | 10 mg/kg IM every eight hours | Quinine or mefloquine to complete 7 days | 4 mg/kg IM | 2 mg/kg IM once daily for 4 days | Quinine or mefloquine to complete 7 days |
Karbwang 1992 THA | 1991 | 15 to 45 yrs | 20 mg/kg IV | 10 mg/kg every eight hours for 7 days | Quinine to complete 7 days | 160 mg IM | 80 mg IM once daily for 6 days | None |
Karbwang 1995 THA | 1994 | 15 to 55 yrs | 20 mg/kg IV | 10 mg/kg every eight hours for 7 days | Quinine to complete 7 days | 160 mg IM | 80 mg IM once daily for 6 days | None |
Seaton 1998 PNG | 1995 | > 12 yrs | 20 mg/kg IV | 10 mg/kg IV every eight hours | Quinine to complete 7 days | 3.2 mg/kg IM | 1.6 mg/kg IM once daily for 4 days | None |
IM = intramuscular; IV = intravenous.