Table 3.

Characteristics of trials comparing artemether and quinine in adults

Trial ID	Year of study	Age limits	Quinine dosing schedule			Artemether dosing schedule
			Loading dose	Maintainance	Follow‐on therapy	Loading dose	Maintainance	Follow‐on therapy
Hien 1996 VNM	1996	15 to 79 yrs	20 mg/kg IM	10 mg/kg IM every eight hours	Quinine or mefloquine to complete 7 days	4 mg/kg IM	2 mg/kg IM once daily for 4 days	Quinine or mefloquine to complete 7 days
Karbwang 1992 THA	1991	15 to 45 yrs	20 mg/kg IV	10 mg/kg every eight hours for 7 days	Quinine to complete 7 days	160 mg IM	80 mg IM once daily for 6 days	None
Karbwang 1995 THA	1994	15 to 55 yrs	20 mg/kg IV	10 mg/kg every eight hours for 7 days	Quinine to complete 7 days	160 mg IM	80 mg IM once daily for 6 days	None
Seaton 1998 PNG	1995	> 12 yrs	20 mg/kg IV	10 mg/kg IV every eight hours	Quinine to complete 7 days	3.2 mg/kg IM	1.6 mg/kg IM once daily for 4 days	None

IM = intramuscular; IV = intravenous.