Skip to main content
. 2014 Sep 11;2014(9):CD010678. doi: 10.1002/14651858.CD010678.pub2

Table 6.

Optimal information size calculations; dichotomous outcomes

Outcome Type of test Proportion in control group3 Proportion in Intervention group Estimated RR Total sample size1,2
Death Superiority 0.17 0.136 0.80 3514
Equivalence 0.17 0.14 to 0.204 ‐ 6592
Neurological sequelae Superiority 0.25 0.20 0.80 2184
Equivalence 0.25 0.22 to 0.284 ‐ 8760

1 These calculation were performed using a power calculator available at: http://www.sealedenvelope.com/power/ 2 All calculation were performed for a power of 80% and an α error of 0.05. 3 The proportion in the control group is taken from the median control group risk across trials. 4 A maximum 3% risk difference was chosen to represent equivalence.