Table 7.
Outcome | Type of test | Mean in control group3 | Mean in Intervention group4 | SD of outcome | Total sample size1,2 |
Coma resolution time | Superiority | 25 | 19 | 20 | 350 |
Equivalence | 25 | 19 to 31 | 20 | 382 | |
Parasite clearance time | Superiority | 42 | 36 | 20 | 350 |
Equivalence | 42 | 36 to 48 | 20 | 382 | |
Fever clearance time | Superiority | 48 | 42 | 20 | 350 |
Equivalence | 48 | 36 to 54 | 20 | 382 |
1 These calculations were performed using a power calculator available at: http://www.sealedenvelope.com/power/ 2 All calculation were performed for a power of 80% and an α error of 0.05. 3 The mean in the control group is taken from the median control group across studies. 4 A six‐hour time difference was chosen to represent a clinically important benefit.