Ojuawo 1998 NGA

Methods	Trial design: RCT Trial dates: Not stated
Participants	Number of participants: 37 children enrolled (age range not stated) Inclusion criteria: Children with unrousable coma, asexual forms of P. falciparum parasitaemia and no other identifiable cause of coma. Exclusion criteria: None stated
Interventions	1. Intramuscular artemether Loading dose of 3.2 mg/kg on admission Followed by 1.6 mg/kg 12 hours later Then 1.6 mg/kg once daily for two days 2. Intravenous quinine Loading dose of 10 mg/kg infused over two hours Followed by 10 mg/kg every eight hours until patient regained consciousness then switched to oral dose for a total of seven days
Outcomes	Outcomes included in the review: Death Coma resolution time Neurologic sequelae Fever clearance time Percentage of children with parasites clearance at days 3 and 7 Outcomes not included in the review: None
Notes	Location: University of Ilorin Teaching Hospital, Nigeria Transmission: Unknown Funding: None stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Patients were randomly assigned to either of the two treatment modalities".
Allocation concealment (selection bias)	Unclear risk	Insufficient information about the sequence generation process to permit judgement.
Blinding (performance bias and detection bias) Objective outcome: Death	Low risk	Unlikely to be biased whether blinding was done or not.
Blinding (performance bias and detection bias) Subjective outcomes: Others	High risk	No information about blinding provided by trial authors. Blinding unlikely as artemether and quinine were given by 2 different routes.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses to follow‐up recorded.
Selective reporting (reporting bias)	Low risk	Most relevant outcomes reported.
Other bias	Low risk	No other bias identified.