Olumese 1999 NGA

Methods	Trial design: Open label RCT Trial dates: Not stated
Participants	Number of participants: 103 children aged 11 months to five years enrolled Inclusion criteria: Children aged six months to 5 years satisfying the WHO criteria for cerebral malaria, viz. unrousable coma lasting more than 30 minutes (with or without convulsions) with the presence of peripheral P. falciparum parasitaemia were included in the trial. Exclusion criteria: None stated
Interventions	1. Intramuscular artemether Loading dose of 3.2 mg/kg on admission Followed by 1.6 mg/kg once daily for four days 2. Intravenous quinine (Lemquine®) Loading dose of 20 mg/kg infused over four hours Followed by 10 mg/kg infused over two hours given every eight hours until the patient is conscious and oral quinine continued at 10 mg/kg orally every eight hours to complete a total of 21 doses or seven days Loading dose quinine was omitted in patients with a positive history of quinine or mefloquine ingestion in the preceding 24 hours before hospital presentation.
Outcomes	Outcomes included in the review: Death Parasite clearance time Fever clearance time Survival and neurological symptoms Coma recovery time Neurological deficits Blood transfusions Outcomes not included in the review: Time to full ambulation
Notes	Location: Emergency Paediatric ward, University College Hospital, Ibadan, Nigeria Transmission: Unknown Funding: World Bank/UNDP/WHO special fund for Research and Training in Tropical Diseases (TDR)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated allocation.
Allocation concealment (selection bias)	Unclear risk	Methods not described by trial authors.
Blinding (performance bias and detection bias) Objective outcome: Death	Low risk	Unlikely to be biased whether blinding was done or not.
Blinding (performance bias and detection bias) Subjective outcomes: Others	High risk	No information of blinding reported by authors. Blinding unlikely as artemether and quinine were given by 2 different routes.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses to follow‐up recorded.
Selective reporting (reporting bias)	Low risk	No evidence of selective reporting.
Other bias	Low risk	No other bias identified.