Walker 1993 NGA

Methods	Trial design: Open RCT Trial dates: Not stated
Participants	Number: 54 children aged one to five years enrolled Inclusion criteria: Patients were admitted if they satisfied the strict WHO definition of cerebral malaria. Exclusion criteria: None stated
Interventions	1. Intramuscular artemether Loading dose of 3.2 mg/kg on admission Followed by 1.6 mg/kg for four days 2. Intravenous quinine Loading dose of 20 mg/kg infused over four hours on admission Followed by 10 mg/kg every eight hours until patient regained consciousness and oral medication was continued at 10 mg/kg, every eight hours for a total of seven days
Outcomes	Outcomes included in the review: Death Coma resolution time Neurological sequelae Fever clearance time Parasite clearance time Adverse effects Outcomes not included in the review: Time to sit unaided Time to drink Discharge packed cell volume Mortality rate 28th day cure rate Parasite recrudescence
Notes	Location: University College Hospital, Ibadan, Nigeria Transmission:Unknown Funding: World Bank/UNDP/WHO special fund for Research and Training in Tropical Diseases (TDR)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random numbers used.
Allocation concealment (selection bias)	Low risk	"Each child was then assigned a random number from a list prepared by an independent collaborator and thus allocated at random to receive either intramuscular artemether or intravenous quinine".
Blinding (performance bias and detection bias) Objective outcome: Death	Low risk	An open‐label trial is unlikely to bias an objective outcome like death.
Blinding (performance bias and detection bias) Subjective outcomes: Others	High risk	"This was a randomized, open, controlled study in which no attempt was made to ‘blind’ the investigators, as the test drug and the control drug were given by 2 different routes".
Incomplete outcome data (attrition bias) All outcomes	Low risk	Only one patient excluded from fever clearance time outcome assessment because of urinary tract infection.
Selective reporting (reporting bias)	Low risk	No evidence of selective reporting.
Other bias	Low risk	No other bias identified.