Study	Reason for exclusion
Aceng 2005	Intervention was rectal artemisinin.
Bhattacharya 1997	Not a RCT.
Bunnag 1992	Drug‐resistant malaria not severe malaria.
Dunyo 2011	Uncomplicated malaria.
Falade 2007	Comparison not parenteral treatment.
Fargier 1999	Not a RCT.
Karbwang 1994	Comparison not parenteral treatment.
Karunajeewa 2006	Not a RCT.
Myint 1987	Not a RCT.
Osonuga 2006	No desired review outcomes.
Reham 2012	Patients not randomly selected (non‐probability consecutive sampling used).
Rehman 2013	Design is a case‐control prospective study.
Shwe 1988	Not a RCT.
Shwe 1992	Participants in the artemether arm also received single dose of mefloquine.
White 1992	Participants not randomized.