3. Sources of heterogeneity for CCA POC test for S. mansoni.

Group	Co‐variate	Subgroup	n (N = 15)	Sensitivity (95% CI)	Specificity (95% CI)
Overall				0.89 (0.86‐0.92)	0.55 (0.46‐0.65)
Subgroup analysis	Reference standarda
		Higher quality (> 1 sample)	5	0.88 (0.82‐0.92)	0.66 (0.46‐0.82)
		Lower quality (1 sample)	13	0.88 (0.85‐0.91)	0.55 (0.45‐0.66)
	Positivity thresholdb	> +1	5	0.72 (0.60‐0.82)	0.85 (0.71‐0.93)
	Age	Children	14	0.90 (0.86‐0.92)	0.56 (0.46‐0.66)
	Intensity of infection	Lightc	3	‐	‐
Sensitivity analysis	QUADAS Patient Selection	Low risk of biasc	3	‐	‐
	QUADAS Reference Standard	Low risk of biasc	0	‐	‐
	QUADAS Flow and Timing	Low risk of bias	11	0.87 (0.84‐0.90)	0.57 (0.49‐0.65)

^aThree studies had data points for evaluations with both a lower‐ and a higher‐quality reference standard.

^bFive studies had data points at both thresholds: trace and +1.

^cInsufficient data for synthesis.