3. Sources of heterogeneity for CCA POC test for S. mansoni.
Group | Co‐variate | Subgroup | n (N = 15) | Sensitivity (95% CI) | Specificity (95% CI) |
Overall | 0.89 (0.86‐0.92) | 0.55 (0.46‐0.65) | |||
Subgroup analysis | Reference standarda | ||||
Higher quality (> 1 sample) | 5 | 0.88 (0.82‐0.92) | 0.66 (0.46‐0.82) | ||
Lower quality (1 sample) | 13 | 0.88 (0.85‐0.91) | 0.55 (0.45‐0.66) | ||
Positivity thresholdb | > +1 | 5 | 0.72 (0.60‐0.82) | 0.85 (0.71‐0.93) | |
Age | Children | 14 | 0.90 (0.86‐0.92) | 0.56 (0.46‐0.66) | |
Intensity of infection | Lightc | 3 | ‐ | ‐ | |
Sensitivity analysis | QUADAS Patient Selection | Low risk of biasc | 3 | ‐ | ‐ |
QUADAS Reference Standard | Low risk of biasc | 0 | ‐ | ‐ | |
QUADAS Flow and Timing | Low risk of bias | 11 | 0.87 (0.84‐0.90) | 0.57 (0.49‐0.65) |
aThree studies had data points for evaluations with both a lower‐ and a higher‐quality reference standard.
bFive studies had data points at both thresholds: trace and +1.
cInsufficient data for synthesis.