Adriko 2014_settingA.

Study characteristics
Patient sampling	Cross‐sectional design; random sampling
Patient characteristics and setting	Species: S. mansoni Country: Uganda Sample size: 100 Age range: 7 to 13 years Participants: children from 1 school from low endemic setting (setting A) Setting: field study Praziquantel status before study: Annual mass treatment had been administered 5 years before study began
Index tests	CCA POC test
Target condition and reference standard(s)	S. mansoni infection measured by stool microscopy (2 Kato‐Katz smears from 1 stool sample)
Flow and timing
Comparative
Notes
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Yes
		Low	Low
DOMAIN 2: Index Test CCA POC
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
Was quality control done?	Unclear
		Unclear	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	No
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
Was quality control done?	Unclear
		High	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Yes
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low