Ashton 2011.

Study characteristics
Patient sampling	Nested case‐control design; unclear sampling
Patient characteristics and setting	Species: S. haematobium and S. mansoni Country: Ivory Coast Sample size: 370 Age range: 5 to 16 years Participants: enrolled children within a study, rapid mapping for soil‐transmitted helminthiasis Setting: field study Praziquantel status before study: not reported
Index tests	CCA POC test (Rapid Medical Diagnostics, Pretoria, South Africa)
Target condition and reference standard(s)	S. haematobium infection measured by urine microscopy (filtration method) and S. mansoni infection by stool microscopy (Kato‐Katz)
Flow and timing
Comparative
Notes
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	No
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Low
DOMAIN 2: Index Test CCA POC
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
Was quality control done?	Unclear
		Unclear	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	No
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
Was quality control done?	Yes
		Unclear	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low