Erko 2013_6KK.

Study characteristics
Patient sampling	Cross sectional design; unclear sampling
Patient characteristics and setting	Species: S. mansoni Country: Ethiopia Sample size: 620 Age range: 8 to 12 years Participants: children from a village in Western Kenya Setting: field study Praziquantel status before study: reported that there had been no treatment in the area
Index tests	CCA POC cassette test (Rapid Medical Diagnostics, Pretoria, South Africa)
Target condition and reference standard(s)	S. mansoni as measured by stool microscopy (3 Kato‐Katz smears on 3 stool samples (6KK))
Flow and timing
Comparative
Notes
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Yes
		Unclear	Low
DOMAIN 2: Index Test CCA POC
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
Was quality control done?	Unclear
		Unclear	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
Was quality control done?	Yes
		Unclear	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low