Shane2011_Colley2013.

Study characteristics
Patient sampling	Cross‐sectional design; consecutive sampling
Patient characteristics and setting	Species: S. mansoni Country: Kenya Sample size: 1845 (updated from Colley 2013) Age range: 1 to 15 years Participants: children from a village in Western Kenya Setting: field study Praziquantel status before study: reported that there had been no treatment in the area
Index tests	CCA POC cassette (Rapid Medical Diagnostics, Pretoria, South Africa)
Target condition and reference standard(s)	S. mansoni infection measured by stool microscopy (Kato‐Katz smears)
Flow and timing
Comparative
Notes	This article was part of a multi‐centre study (Colley 2013). In this article, 2‐by‐2 tables of the CCA POC measured against the first daily stool specimen (duplicate KK smears on 1 stool sample) were presented
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Low
DOMAIN 2: Index Test CCA POC
Were the index test results interpreted without knowledge of the results of the reference standard?	Yes
If a threshold was used, was it pre‐specified?	Yes
Was quality control done?	Yes
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	No
Were the reference standard results interpreted without knowledge of the results of the index tests?	Yes
Was quality control done?	Yes
		High	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Yes
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low