Tchuente 2012_Colley2013.

Study characteristics
Patient sampling	Cross‐sectional design; unclear sampling
Patient characteristics and setting	Species: S. mansoni Country: Cameroon Sample size: 138 Age range: 7 to 15 years Participants: children who provided all 3 samples Setting: field study (low endemicity) Praziquantel status before study: not reported
Index tests	CCA POC test (Rapid Medical Diagnostics, Pretoria, South Africa)
Target condition and reference standard(s)	S. mansoni infection measured by stool microscopy (Kato‐Katz)
Flow and timing
Comparative
Notes	This article describes part of a multi‐centre study (Colley 2013), which was similar to Tchuente 2012_9KK, but in this article, 2‐by‐2 tables of the CCA POC measured against the first daily stool specimen (triplicate KK smears on 1 stool sample) were presented
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Low
DOMAIN 2: Index Test CCA POC
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
Was quality control done?	Yes
		Unclear	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
Was quality control done?	Unclear
		Unclear	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Yes
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	No
		Low