Table 3.
Tract-specific label | Nearest gray matter region | Hemisphere | MNI coordinates | T value | Cluster-level P value a | Cluster size (voxels) | ||
---|---|---|---|---|---|---|---|---|
x | y | z | ||||||
Model 1: ASD > TDC | ||||||||
Splenium of corpus callosum | Precuneus | L | −18 | −48 | 4 | 4.19 | 0.015 | 655 |
Precuneus | L | −19 | −46 | 21 | 3.57 | |||
Posterior cingulate gyrus | L | −16 | −33 | 39 | 3.46 | |||
Splenium of corpus callosum | Posterior cingulate gyrus | R | 21 | −46 | 6 | 3.65 | 0.009 | 715 |
Precuneus | R | 23 | −46 | 24 | 3.46 | |||
Posterior cingulate gyrus | R | 18 | −30 | 30 | 3.27 | |||
Model 2: ASD > TDC | ||||||||
External capsule/anterior corona radiata | Inferior orbitofrontal cortex | R | 23 | 20 | −18 | 4.54 | 0.041 | 537 |
R | 26 | 32 | −11 | 4.04 | ||||
R | 18 | 32 | −18 | 3.64 | ||||
Splenium of corpus callosum | Precuneus | L | −18 | −48 | 4 | 4.31 | 0.016 | 644 |
Precuneus | L | −19 | −46 | 21 | 3.61 | |||
Posterior cingulate gyrus | L | −16 | −33 | 39 | 3.43 | |||
Splenium of corpus callosum | Posterior cingulate gyrus | R | 21 | −46 | 7 | 3.60 | 0.011 | 690 |
Precuneus | R | 23 | −46 | 24 | 3.42 | |||
Posterior cingulate gyrus | R | 18 | −30 | 30 | 3.30 | |||
Model 2: ASD by age > TDC by age | ||||||||
Forceps minor (anterior forceps) | Anterior cingulate gyrus | L | −18 | 45 | 4 | 4.14 | 0.001 | 960 |
L | −25 | 20 | −5 | 3.46 | ||||
L | −18 | 29 | −2 | 3.33 | ||||
Model 3: Adolescent, ASD > TDC | ||||||||
Anterior corona radiata | Anterior cingulate gyrus | R | 12 | 29 | −9 | 4.10 | 0.001 | 1,151 |
R | 29 | 21 | 10 | 3.84 | ||||
R | 26 | 39 | −5 | 3.74 |
ASD, autism spectrum disorder; TDC, typically developing control; L, left; R, right; MNI, Montreal Neurological Institute. aStatistical threshold was all set at FWE-corrected cluster-level P < 0.05, with cluster-forming voxel-level P < 0.005.