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The acute effects of BMS-345541 administered intraperitoneally to adult mdx mice. Inset shows Western blots of p65 and Oct-1 which were obtained from the nuclear extracts of costal hemi-diaphragms isolated 5 hours after drug (100 mg/kg in HEPES Ringer) or vehicle (HEPES Ringer) injection. N is the number of mice and costal hemi-diaphragms. The densitometric results (p65/Oct-1) did not reveal a significant effect of drug administration on nuclear p65 expression.
