Table 1.
Variable | Metformin | Sulfonylurea |
---|---|---|
n | 9103 | 1120 |
Age (years) | 65.0 (10.6)* | 71.3 (10.6)* |
Time from first diabetes diagnosis in practice (years) | 1.3 (2.4) | 1.1 (2.1) |
Males (%) | 50.7* | 47.3* |
Private health insurance (%) | 5.4 | 4.9 |
Diabetologist treatment (%) | 2.6 | 2.4 |
Region (West Germany) (%) | 79.6* | 75.3* |
Urban residencya (%) | 29.4 | 27.9 |
eGFR (ml/min/1.73 m2) | 81.1 (18.8)* | 72.0 (21.0)* |
HbA1c (%)c | 7.3 (1.4)* | 7.6 (1.6)* |
BMI (kg/m2)d | 31.6 (5.2)* | 29.4 (5.1)* |
Diagnosed comorbidity (%) | ||
Coronary heart disease | 28.7* | 37.3* |
Myocardial infarction | 7.4* | 11.0* |
Stroke | 7.1* | 10.7* |
Peripheral vascular disease | 7.2* | 12.9* |
Congestive heart failure | 13.1* | 24.1* |
Hypertension | 81.8 | 82.9 |
Hyperlipidemia | 55.4* | 50.5 |
Retinopathy | 0.9 | 1.4 |
Neuropathy | 4.1 | 4.6 |
Depression | 23.6 | 23.7 |
Charlson comorbidity score | 1.3 (0.9)* | 1.5 (1.2)* |
Cotherapy (%) | ||
ACE inhibitors | 65.6* | 70.8* |
Diuretics | 44.9* | 61.4* |
Statins | 52.8 | 51.9 |
Data are means (SD) or proportions (%). ID, index date of new prescriptions of metformin or SU.
>100 000 inhabitants.
eGFR: estimated glomerular filtration rate (MDRD formula).
Recorded values: MET n = 7658, SU: n = 947.
Recorded values: MET n = 3377, SU: n = 339.
P < .05 metformin vs sulfonylurea group