Table 4.

Pramlintide Placebo and Subcutaneous Pharmacokinetics (PK) and Pharmacodynamics (PD) Predictions Showing RMSE Values.

		Placebo	PK	PD
Reference	Conc. (mcg)	RMSE (mg/dL)	RMSE (pmol/L)	RMSE (mg/dL)
		Kolterman et al22	30	20.66 ± 4.89	2.99 ± 0.57	23.01 ± 5.96
100	17.55 ± 4.89		9.79 ± 3.64	17.13 ± 4.73
300	25.74 ± 6.17		11.71 ± 2.01	18.29 ± 5.15
Fang et al13	30	NA	25.58 ± 5.69	17.02 ± 3.19
	100		274.53 ± 72.42	31.66 ± 5.08
	300		604.41 ± 149.23	42.76 ± 8.07
Thompson et al17	10	16.4 ± 2.71	NA	34.29 ± 5.15
	30	11.17 ± 1.72		36.23 ± 5.23
	100	11.07 ± 1.76		33.86 ± 5.8