Table 2.
Confounding Variables in Glucose Management.
| Methodology affecteda
|
||
|---|---|---|
| Variable | Glucose oxidase (GO) | Glucose-1-dehydrogenase (GDH) |
| Whole blood | ↓ | ↓ |
| Arterial | ↑ | ↑ |
| Capillary | ↑ | ↑ |
| Postprandial state | ↑ | ↑ |
| Hematocrit | ||
| Anemia | ↑ | ↑ |
| Polycythemia | ↓ | ↓ |
| Oxygen concentration | ||
| Hypoxia | ↑ | − |
| Oxygen therapy | ↓ | − |
| pH (6.8-7.55) | ||
| Low pH | −/↓ | − |
| High pH | −/↑ | − |
| Hypothermia | ↑ | ↓/↑ |
| Hypotension | ↑ | ↓/↑ |
| Drugs | ||
| Ascorbic acid | ↓ | ↑/− |
| Acetaminophen | ↓ | ↑ |
| Dopamine | − | ↓ |
| Icodextrin | − | ↑ |
| Mannitol | ↑ | − |
Source: Copyright © 2007 American Diabetes Association. From Diabetes Care. 2007;30:403-409. Reprinted with permission from the American Diabetes Association.
a
Change relative to venous plasma sample measured at central laboratory.