Table 3.
Multivariate Hazard Ratios for Graft Failure, Death-Censored Graft Failure, and Recipient Mortality by Recipient Age Cohort. Reference = medium quality kidneys (KDPI 51–60th percentile; HR =1.00 – not shown).
| Recipient Age (years) | Organ Quality (KDPI Quintile) | |||
|---|---|---|---|---|
| Very High (0–20th percentile) | High (21–40th percentile) | Low (61–80th percentile) | Very Low (81–100th percentile) | |
| Uncensored Graft Failure (HR (95% CI), p value) | ||||
| 30–39 | 0.78 (0.74–0.81) p<0.001 |
0.84 (0.80–0.88) p<0.001 |
1.13 (1.08–1.18) p<0.001 |
1.41 (1.34–1.47) p<0.001 |
| 40–49 | 0.78 (0.75–0.81) p<0.001 |
0.82 (0.79–0.85) p<0.001 |
1.10 (1.06–1.14) p<0.001 |
1.51 (1.45–1.56) p<0.001 |
| 50–59 | 0.80 (0.77–0.83) p<0.001 |
0.80 (0.77–0.84) p<0.001 |
1.13 (1.09–1.16) p<0.001 |
1.41 (1.37–1.45) p<0.001 |
| 60–69 | 0.80 (0.77–0.83) p<0.001 |
0.80 (0.77–0.84) p<0.001 |
1.13 (1.09–1.16) p<0.001 |
1.41 (1.37–1.45) p<0.001 |
| 70–79 | 0.88 (0.80–0.97) p=0.009 |
0.77 (0.70–0.85) p<0.001 |
1.05 (0.97–1.14) p=0.22 |
1.42 (1.33–1.51) p<0.001 |
| >79 | 0.90 (0.75–1.07) p=0.24 |
0.89 (0.74–1.06) p=0.20 |
1.08 (0.94–1.24) p=0.28 |
1.26 (1.13–1.41) p<0.001 |
| Death-Censored Graft Failure (HR (95% CI), p value) | ||||
| 30–39 | 0.75 (0.71–0.79) p<0.001 |
0.81 (0.78–0.86) p<0.001 |
1.17 (1.11–1.22) p<0.001 |
1.47 (1.47–1.55) p<0.001 |
| 40–49 | 0.72 (0.69–0.76) p<0.001 |
0.78 (0.74–0.82) p<0.001 |
1.16 (1.12–1.21) p<0.001 |
1.62 (1.56–1.69) p<0.001 |
| 50–59 | 0.66 (0.63–0.70) p<0.001 |
0.75 (0.71–0.79) p<0.001 |
1.21 (1.16–1.27) p<0.001 |
1.75 (1.68–1.82) p<0.001 |
| 60–69 | 0.64 (0.60–0.69) p<0.001 |
0.70 (0.65–0.75) p<0.001 |
1.22 (1.15–1.29) p<0.001 |
1.89 (1.80–1.98) p<0.001 |
| 70–79 | 0.68 (0.55–0.83) p<0.001 |
0.75 (0.62–0.91) p=0.003 |
1.11 (0.95–1.28) p=0.19 |
1.90 (1.69–2.12) p<0.001 |
| >79 | 0.46 (0.28–0.70) p<0.001 |
1.03 (0.73–1.41) p=0.88 |
1.08 (0.82–1.41) p=0.59 |
1.63 (1.33–2.01) p<0.001 |
| Recipient Mortality (HR (95% CI), p value) | ||||
| 30–39 | 0.84 (0.78–0.91) p<0.001 |
0.88 (0.82–0.95) p=0.002 |
1.04 (0.96–1.13) p=0.31 |
1.26 (1.15–1.37) p<0.001 |
| 40–49 | 0.87 (0.82–0.91) p<0.001 |
0.89 (0.85–0.94) p<0.001 |
1.01 (0.96–1.07) p=0.61 |
1.33 (1.25–1.40) p<0.001 |
| 50–59 | 0.85 (0.82–0.89) p<0.001 |
0.87 (0.83–0.90) p<0.001 |
1.08 (1.04–1.12) p=0.002 |
1.34 (1.29–1.39) p<0.001 |
| 60–69 | 0.86 (0.82–0.90) p<0.001 |
0.85 (0.82–0.89) p<0.001 |
1.10 (1.06–1.14) p<0.001 |
1.25 (1.20–1.29) p<0.001 |
| 70–79 | 0.93 (0.84–1.03) p=0.16 |
0.77 (0.69–0.85) p<0.001 |
1.03 (0.94–1.13) p=0.51 |
1.29 (1.20–1.39) p<0.001 |
| >79 | 0.99 (0.82–1.18) p=0.87 |
0.89 (0.73–1.07) p=0.24 |
1.08 (0.93–1.25) p=0.31 |
1.19 (1.05–1.34) p=0.006 |