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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Neurobiol Dis. 2014 Aug 29;71:345–358. doi: 10.1016/j.nbd.2014.08.027

Figure 5. Analysis of neuropathology in conditional R1441C LRRK2 transgenic mice.

Figure 5

Representative photomicrographs from immunohistochemical analysis of the substantia nigra pars compacta of R26-LRRK2+/+/DAT-Cre and R26-LRRK2+/+ mice at 22 months of age. Sections were processed with Gallyas silver stain or antibodies detecting ubiquitin, the autophagosome marker LC3, the autophagy substrate p62/sequestosome, astrocytic marker GFAP, tau phosphorylated at Ser202 (clone CP13), tau pathological conformation (clone MC1), tau phosphorylated at Ser396/Ser404 (clone PHF-1), total α-synuclein, and α-synuclein phosphorylated at Ser129 (P-α-synuclein). Insets display higher magnification images. Scale bar: 50 μm.