Table 1. Sholl analysis of TH-positive neurons from R26-LRRK2+/+/DAT-Cre mice.
Measurement | R26-LRRK2+/+ | R26-LRRK2+/+/DAT-Cre | |
---|---|---|---|
Sholl coefficient (-log slope of regression fit) | Measure of overall neurite complexity | -0.0219 ± 0.0018 | -0.0141 ± 0.0012* (P = 0.007) |
Schoenen ramification index | Average number of branches formed per primary branch | 1.69 ± 0.168 | 2.15 ± 0.213 (P = 0.0910) |
Critical radius (μm) | Sholl radius at which there is max number of intersections | 134.5 ± 21.7 | 231.0 ± 31.5* (P = 0.0137) |
indicates significant difference (unpaired, two-tailed Student's t-test)