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. 2012 Feb;5(Suppl 1):i3–i14. doi: 10.1093/ndtplus/sfr163

Table 1.

Comparison of magnesium and calcium differences and similarities [13, 5, 7, 10, 16, 21, 2327]

Magnesium Calcium
Chemical aspects
Name (symbol) Magnesium (Mg) Calcium (Ca)
Element category Alkaline earth metal Alkaline earth metal
Abundance Eighth most abundant element in the crust of the Earth Fifth most abundant element in the crust of the Earth
Atomic number 12 20
Valence 2 2
Crystal structure Hexagonal Face-centered cubic
Atomic radius 0.65 Å 0.94 Å
Atomic weight 24.305 g/mol 40.08 g/mol
Specific gravity 1.738 (20°C) 1.55 (20°C)
Number of hydration shells Two layers One layer
Radius after hydration ∼400 × larger than its dehydrated form ∼25 × larger than its dehydrated form
Isotopes Magnesium naturally exists in three stable isotopes: Calcium has five stable isotopes:
[24]Mg (most abundant isotope) [40]Ca (most abundant isotope)
[25]Mg [42]Ca
[26]Mg [43]Ca
[28]Mg radioactive, β-decay [44]Ca
[46]Ca
Physiological aspects
Availability in the human body Normal serum concentration range: 0.65–1.05 mmol/L, divided into three fractions: Normal serum concentration range: 2.2–2.6 mmol/L, divided into three fractions:
Free, ionized (ultrafilterable fraction): 55–70% Free, ionized (ultrafilterable fraction): 47.5–50%
Protein-bound (non-ultrafilterable): 20–30% Protein-bound (non-ultrafilterable): 42–46%
Complexed (citrate, bicarbonate, phosphate): 5–15% Complexed (citrate, bicarbonate, phosphate): 6.0–6.5%
Total body content in adults ∼24 g ∼1000 g
Function with respect to cell death Anti-apoptotic Pro-apoptotic
Information attained by serum level Serum level does not represent total body content Serum level does not represent total body content