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. Author manuscript; available in PMC: 2015 Jun 4.
Published in final edited form as: Nature. 2015 Mar 18;520(7545):57–62. doi: 10.1038/nature14344

Extended Data Table 1. p53-regulated genes identified in the wild-type p53 inducible stable line through microarray analysis.

Functional group Gene symbol Gene name RefSeq Fold Change p-value
Transports Metabolism TIGAR TP53-induced glycolysis and apoptosis regulator AY425618 4.55812 2.3798E-07
SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 AB026891 -2.66607 7.0681 E-05
GLS2 glutaminase 2 (liver, mitochondrial) AF110330 17.0011 4.8505E-09
SESN1 sestrin 1 AF033122 9.78117 8.93E-09
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) AB012644 2.95728 7.1604E-08
PANK1 pantothenate kinase 1 AY027661 5.72688 1.456E-06
ACER2 similar to alkaline ceramidase 2; alkaline ceramidase 2 ENST00000340967 5.34687 1.1182E-05
SESN2 sestrin 2 BC013304 2.59232 7.8217E-06
CHAC1 ChaC, cation transport regulator homolog 1 (E. coli) BC001683 4.81706 4.0584E-08
ORAI3 ORAI calcium release-activated calcium modulator 3 BC015555 3.23129 7.6884E-06
ABHD4 abhydrolase domain containing 4 AK293198 10.3618 1.1017E-09
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 AK300373 13.0247 6.7912E-08
ANK1 ankyrin 1, erythrocytic M28880 2.72917 3.7932E-06
BCAT1 branched chain aminotransferase 1, cytosolic ENST00000261192 -2.64027 3.6497E-07
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) ENST00000510532 5.0088 4.8907E-07
DGKA diacylglycerol kinase, alpha 80kDa BC023523 5.92523 5.4931 E-07
FDXR ferredoxin reductase AK298908 7.05275 1.1567E-09
PHGDH phosphoglycerate dehydrogenase AF171237 -1.31044 5.8696E-05
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 AL833351 2.78579 9.8714E-07
KLHL24 kelch-like 24 (Drosophila) AK000066 2.50394 1.6715E-06
LRP1 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) AK122840 3.52784 1.1368E-08
TM7SF2 transmembrane 7 superfamily member 2 AF096304 6.93921 2.5897E-08
Cell cycle & Proliferation CDKN1A/p21 cyclin-dependent kinase inhibitor 1A (p21, Cip1) AK298901 10.9225 3.0979E-09
BTG2 BTG family, member 2 BC105948 14.9562 6.8143E-09
GADD45A growth arrest and DNA-damage-inducible, alpha BC011757 2.93357 1.0756E-07
CAV1 caveolin 1, caveolae protein, 22kDa AK290871 2.65042 3.2047E-07
CCNK cyclin K BT006950 2.90074 9.9132E-07
DUSP1 dual specificity phosphatase 1 AK298047 3.06448 6.6673E-10
PLK2 polo-like kinase 2 (Drosophila) AK297298 5.30746 2.2421 E-08
PLK3 polo-like kinase 3 (Drosophila) AJ293866 18.2063 9.4625E-10
RB1 retinoblastoma 1 AK299179 2.69757 1.4404E-07
SFN stratifin AF029082 3.45591 7.6309E-06
TRIM22 tripartite motif-containing 22 AK298934 2.81865 5.2447E-05
FBXW7 F-box and WD repeat domain containing 7 AF411971 3.23697 9.4834E-06
ZMAT3 zinc finger, matrin type 3 AF355465 5.73607 6.5446E-08
CCNE2 cyclin E2 AF102778 -10.5563 9.6454E-09
MNS1 meiosis-specific nuclear structural 1 ENST00000260453 -2.97374 0.00015946
Apoptosis BAX BCL2-associated X protein L22474 1.88726 3.7902E-06
TP53INP1 tumor protein p53 inducible nuclear protein 1 AF409115 12.3711 6.2069E-09
TP53I3 tumor protein p53 inducible protein 3 ENST00000407482 15.126 2.3803E-09
TNFRSF10D death domain AF021233 2.82197 4.2642E-07
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 AF337957 2.9952 5.8401 E-07
APAF1 apoptotic peptidase activating factor 1 AF013263 10.2862 4.0106E-10
CASP6 caspase 6, apoptosis-related cysteine peptidase BC000305 9.60075 2.8464E-08
GDF15 growth differentiation factor 15 AB000584 13.1249 1.1527E-08
PCBP4 poly(rC) binding protein 4 AF176330 4.50693 9.552E-09
PERP PERP, TP53 apoptosis effector BC010163 3.02863 1.9567E-08
RPS27L ribosomal protein S27-like BC003667 3.53852 1.0771 E-05
SCN3B sodium channel, voltage-gated, type III, beta BC117282 8.94659 4.3472E-08
DDIT3 DNA-damage-inducible transcript 3 BC003637 2.63317 0.0001017
Others DRAM1 DNA-damage regulated autophagy modulator 1 BC018435 3.67323 7.8723E-08
MDM2 MDM2 oncogene, E3 ubiquitin protein ligase AF092845 7.44673 5.4175E-08
RRM2B ribonucleotide reductase M2 B (TP53 inducible) ENST00000395910 4.53617 4.0021 E-07
XPC xeroderma pigmentosum, complementation group C ENST00000285021 2.72401 4.349E-05
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit AK301165 3.35515 1.2744E-07
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 AF251051 12.5615 2.8927E-06
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C AF165520 4.85886 3.1852E-08
ARID5B AT rich interactive domain 5B (MRF1-like) AK296921 3.56829 3.3834E-07
BMP6 bone morphogenetic protein 6 AK300628 -3.88207 7.2324E-07
C4ORF21 chromosome 4 open reading frame 21 AK090556 -3.97572 1.401E-06
C5ORF28 chromosome 5 open reading frame 28 BC013351 -3.03553 5.0792E-05
CALCOCO1 calcium binding and coiled-coil domain 1 AB040969 5.94756 3.9553E-08
FERMT1 fermitin family homolog 1 (Drosophila) AB105105 4.28817 6.2732E-07
GATS GATS, stromal antigen 3 opposite strand AK124689 4.13525 1.1626E-07
MR1 major histocompatibility complex, class l-related AF010446 4.56814 2.5677E-07
PCDHB11 protocadherin beta 11 BC112132 4.26781 3.3776E-05
PCDHB14 protocadherin beta 14 AF152493 2.76533 9.4183E-05
PLXNB2 plexin B2 AK056543 2.79781 1.2076E-08
PROCR protein C receptor, endothelial (EPCR) BC014451 3.27997 6.7976E-08
VCAN versican ENST00000343200 15.2705 2.7969E-07
WDR63 WD repeat domain 63 ENST00000294664 19.3466 1.204E-08
ZNF702P zinc finger protein 702 pseudogene NR_003578 3.99824 3.3623E-05