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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Trends Neurosci. 2014 Dec 30;38(3):129–138. doi: 10.1016/j.tins.2014.12.005

Figure 1.

Figure 1

Altered relationship between cortical activation and subcortical dopamine function in subjects at Ultra High Risk of Psychosis (UHR). (A) Functional activation in the left inferior frontal gyrus (IFG) during verbal fluency is positively correlated with presynaptic dopaminergic activity in the associative striatum [108]. (B) Functional activation in the right IFG during working memory is positively correlated in healthy controls but negatively correlated in UHR subjects [107]. (C) Functional activation in the medial temporal lobe (MTL) during verbal encoding is positively correlated with subcortical dopamine levels in UHR subjects but not in healthy controls [105]. (D) MTL activation during verbal recognition was negatively correlated with dopamine levels in the healthy control group but not in the UHR group [105]. (E) Abnormal interaction between functional activation in right hippocampus and subcortical dopamine function during the processing of reward salience [106]. Ki = 18F-fluorodopa influx constants. All figures adapted with permission from the author’s original work.