TABLE 1.

Multimodal imaging studies in people at Ultra High Risk of psychosis.

Ref.	Modalities	Findings	HC			UHR
			n	Age	M/F	n	Age (SD)	M/F
Roiser et al., 2013	fMRI (salience attribution task) & 18F-DOPA PET	UHR: negative correlation between striatal dopamine synthesis capacity and hippocampal activation to irrelevant stimulus features. HC: opposite correlation	18	26.5 (6)	10/8	18	25.7 (4.3)	7/11
Schobel et al., 2013	Perfusion MRI & sMRI	UHR: Hippocampal hypermetabolism at baseline predicted hippocampal atrophy, which occurred during progression to psychosis	-	-	-	$\frac{15\text{NP}}{10\mathrm{P}}$	$\frac{19.3(3.9);}{20.4(3.6)}$	$\frac{13/2;}{9/1}$
Allen et al., 2012	fMRI (episodic memory task) & 18F-DOPA PET	UHR: positive correlation between hippocampal activation during memory task and 18F-DOPA uptake. HC: opposite correlation	14	25.7 (4.1)	9/5	20	26.3 (5.1)	10/10
Fusar-Poli et al., 2011	fMRI (VF task) & 18F-DOPA PET	UHR: positive correlation between striatal dopamine synthesis capacity and activation in the IFC. HC: no correlation	14	25.5 (3.6)	10/4	20	26.7 (5)	11/9
Fusar-Poli et al., 2011	fMRI (VF task) & 1H-MRS	UHR: positive association between thalamic glutamate levels and activation in hippocampus and in temporal cortex; negative association between thalamic glutamate levels and activation in prefrontal cortex. HC: opposite correlation in the prefrontal and temporal cortex and in the hippocampus.	17	25.5 (3.6)	10/7	24	26.7 (5)	23/1
Valli et al., 2011	fMRI (episodic memory task) & 1H-MRS	HC: positive correlation between MTL activation during episodic encoding and MTL glutamate. UHR: no correlation	14	25.6 (3.7)	6/8	22	25.72 (4.9)	12 / 10
Fusar-Poli et al., 2010	fMRI (WM task) & 18F-DOPA PET	UHR: negative correlation between striatal dopamine synthesis capacity and prefrontal activation. HC: opposite correlation	14	25.5 (3.6)	-	20	26.6 (5)	-
Stone et al., 2010	1H-MRS & 18F-DOPA PET	UHR: negative relationship between hippocampal glutamate levels and striatal dopamine synthesis capacity. HC: no correlation	12	-	-	16	-	-
Stone et al., 2009	1H-MRS & sMRI	UHR: level of thalamic glutamate positively correlated with GMV in the MTL and insula. HC: no correlation	27	25 (4)	14/13	27	25(5)	19/8

Note: CBV, Cerebral Blood Volume; FG, Frontal Gyrus; fMRI, functional magnetic resonance imaging; Glx, glutamate plus glutamine; GMV, Gray Matter Volume; HC, Healthy Controls; IFG, Inferior Frontal Gyrus; MMN, Mismatch Negativity; MRS, magnetic resonance spectroscopy; MTL, Medial Temporal Gyrus; NP, No Psychosis; P; Psychosis; R, Right; sMRI, structural magnetic resonance imaging; UHR, Ultra High Risk; VF, verbal fluency; WM, working memory; WMV, White Matter Volume.