Table 3.

Pharmacokinetic parameters of 25 mg/kg 1,2- ¹³C-DCA and urinary MA after 5 days of 1 g of ¹²C-CH.

Parameter	Units	DCA fast metabolizers day 6						DCA slow metabolizers day 6
		Pt 2 EGT/EGT	Pt 3 EGT/EGM	Pt 4 EGT/EGT	Pt 9 EGT/EGT	Avg.	St. dev.	Pt 5 KRT/EGM	Pt 8 KGT/EGM	Pt 10 KGT/KGT	Pt 11 KRT/EGM	Avg.	St. dev.
Elimination half life	min	75.1	119.8	135.5	49.9	95.1	39.5	80.7	52.0	67.0	97.8	74.3	19.5
Cmax	μg/mL	52	50	62	49.8	53.5	5.8	65	54	69.3	31.4	54.9	17.0
AUC	min* μg/mL	9460	10,156	11,276	6654	9387	1969	6716	8068	10,058	3834	7169	2613
Clearance	mL/min	2.6	2.5	2.2	3.8	2.8	0.7	3.7	3.1	2.5	6.5	4.0	1.8
12C-DCA	μg/mL	1.7	1.2	2.4	1.5	1.7	0.5	2	1.6	1.3	1.4	1.6	0.3
MA	μg/g C	0.2	0.3	0.5	0.4	0.4	0.1	0.2	0.4	0.3	0.7	0.4	0.2

AUC, area under curve; Cmax, maximum concentration; MA, maleylacetone.