Table 1.

Examples of recent developments and successes of genome-scale modeling in metabolic engineering

Publication	Year	Target	Organism
Lee et al. [49]	2002	Succinic acid production	E. coli
Alper et al. [5]	2005	Lycopene production	E. coli
Bro et al. [16]	2006	Decrease glycerol and increase ethanol yield	S. cerevisiae
Lee et al. [48]	2007	Threonine production	E. coli
Park et al. [66]	2007	l-valine production	E. coli
Song et al. [90]	2008	Optimize media and succinic acid production	M. succiniciproducens
Meijer et al. [56]	2009	Succinic acid production	A. niger
Ohno et al. [62]	2013	Butanol, propanol, propanediol production	E. coli
Sun et al. [93]	2014	Terpenoid biosynthesis	S. cerevisiae
Borodina et al. [15]	2015	3-Hydroxypropionic acid biosynthesis	S. cerevisiae