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. 2015 Jun 5;15:3. doi: 10.1186/s12899-015-0017-5

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© Alexeev et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Design of the animal study. On d2, rat pups were randomized to litters of 10/dam (Normal growth (N), five males and five females) or 16/dam (Restricted growth (R), eight males and eight females). On d11, R pups were re-randomized into litters creating catch-up (R-6, 6 pups/dam), normal (R-10, 10 pups/dam) or reduced growth (R-16, 16 pups/dam) groups. N pups remained in litters of 10 pups/dam (N-10)