Fig. 1.

Effect of 4 weeks of High-fat Diet on Insulin Tolerance. Mice were fed either a RD (squares) or HF diet (circles) for 4 weeks before being subjected to an intra-peritoneal insulin tolerance test to assess glucose disposal at 0–180 min post-insulin injection. The area under the curve (AUC) was measured from each graph and presented in the bar graphs (panels ii) to the right. Values are expressed as mean ± SEM. *P <0.05 versus RD-water