Table 1.
Fraction | Protein (mg) | Yield (%) | Approximate fold purification | |
---|---|---|---|---|
Total extract | 1 100 | 100 | 1 | |
I | Crude membrane | 109 | 80 | 8 |
II | Flotation | 35 | 75 | 24 |
III | Velocity gradient | 26 | 70 | 29 |
IV | Detergent extract | 1.4 | 55 | 432 |
Pores were purified as described in Materials and Methods, and the fold-enrichment was determined by densitometric scanning of western blots of the fractions, probing for the nucleoporin Nup93. Fractions I–IV correspond to those in Figure 1C.