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. Author manuscript; available in PMC: 2015 Jun 4.
Published in final edited form as: J Urol. 2014 Oct 5;193(4):1353–1360. doi: 10.1016/j.juro.2014.09.108

Figure 2.

Figure 2

A to F, OPT of 6.5-week penis at indifferent stage of development stained with E-cadherin. G to K, histological sections correspond to horizontal lines in gross OPT specimen. G and H, note extensive proliferation (Ki67) along urethral plate (UP), urethral meatus (UM) and areas of urethral plate canalization (Canal), ie “opening zipper.” I and J, high power images of G and H. K, caspase 3 was not expressed, in contrast to Ki67 in I and J, supporting role of cellular proliferation over apoptosis as means of urethral plate/groove development. EB, erectile body.