Figure 2.

(A) Relationship between f_mCYP3A and AUCR for ketoconazole-mediated inhibition of CYP3A. Combined effect of liver and intestine (solid line) and liver only (dashed line). AUCR thresholds of 1.25, 2 and 5 shown as horizontal dotted lines. (B) Comparative relationship between AUCR and f_mCYP3A for ketoconazole (solid line) and itraconazole (dashed line) using the liver and intestine model. (C) Observed AUCR on co-administration with strong or moderate CYP3A inhibitors. Diltiazem (dark grey), itraconazole (medium grey) and ketoconazole (light grey)