Fig 2. S. haematobium eggs induce differential methylation of multiple members of the Wnt signaling pathway, including the bladder cancer-associated tumor suppressor gene Wif1.

Differentially methylated gene members of the Wnt signaling pathway are circled in red. Note that Wif1, a tumor suppressor gene implicated in bladder carcinogenesis, is differentially methylated and sits far upstream along the Wnt pathway. Figure generated using DAVID (http://david.abcc.ncifcrf.gov/).