Table 3. Multivariable linear regression analysis of 10 Years Risk of CHD (Ln transformed) with serum Na+ and Glucose as predictor variables (ARIC Study).
Predictive capability of independent variables | Analysis of variance | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Dependent variable:Ln(10 Years Risk of CHD) | Na+, mmol/l | Glucose, mmol/l | ||||||||
Intercept | Coefficient | t | P | Coefficient | t | P | F | P | ||
All participants (N = 12779) | -1.86 | 0.017 | 4.2 | <0.001 | 0.165 | 34.5 | <0.001 | 598 | <0.001 | |
*No BP Medications (N = 10336) | -2.50 | 0.020 | 4.2 | <0.001 | 0.176 | 29.4 | <0.001 | 432 | <0.001 | |
BP Medications (N = 3319) | 0.29 | 0.009 | 1.6 | n.s. | 0.082 | 16.4 | <0.001 | 138 | <0.001 | |
*Glucose < 6.5 mmol/l (N = 9360) | -3.67 | 0.012 | 2.4 | 0.02 | 0.61 | 25.0 | <0.001 | 319 | <0.001 | |
*White | Men (N = 3788) | -0.25 | 0.012 | 2.9 | 0.004 | 0.14 | 20.1 | <0.001 | 202 | <0.001 |
Women (N = 4453) | -7.84 | 0.051 | 8.6 | <0.001 | 0.23 | 24.8 | <0.001 | 328 | <0.001 | |
*Black | Men (N = 896) | 0.23 | 0.007 | 0.9 | n.s. | 0.09 | 12.8 | <0.001 | 86 | <0.001 |
Women (N = 1199) | -4.14 | 0.027 | 2.7 | 0.006 | 0.15 | 17.0 | <0.001 | 145 | <0.001 |
Serum Na+ and glucose are significant predictors of the 10 Years Risk of CHD when all study participants are included in analysis and in the following subsets: people who do not take blood pressure medications, people with blood glucose concentration lower than 6.5 mmol/l, white men, white women and black men.
* Participants who took blood pressure medications were excluded from the analysis